Metrics details Abstract The clinical data Table 1 and pulmonary physiologic findings Table 2 in nine patients with rheumatoid arthritis RA and in five patients with systemic lupus erythematosus SLE are described.
Only 5 patients with RA showed roentgenologic evidence of a diffuse involvement of lowering standards dating lungs. Yet in all cases a marked lowering of the diffusing capacity CO-single-breath-method was found.
This defect in diffusion tended to be associated with restriction and when investigated with alveolar hyperventilation. Although the mean values of group I are lower, statistically no significant difference was meine stadt aachen partnersuche. The findings demonstrate that a lowered diffusing capacity may indicate a pulmonary involvement in patients with RA or SLE when other physiologic, clinical or roentgenologic criteria are normal.
This is documented by one case, in which the pulmonary manifestation, suspected by a defect in lowering standards dating standards dating, was proved histologically although thex-ray lowering standards dating normal Fig.
In addition, the measurement of the diffusing capacity appears to be an ideal method to observe the progression of the pulmonary involvement and to evaluate the response to treatment.
In patients with RA the abnormal diffusion may be the indication for therapy with corticosteroids.
The high incidence of normal roentgenologic findings associated with a diffusion defect in our study may explain the difficulty other authors had to demonstrate a statistically significant correlation between RA and pulmonary manifestation when only roentgenologic symptoms were taken as criteria.
The functional and morphologic reasons for the lowering of the diffusing capacity are discussed, as is the value of pulmonary physiologic measurements in the study of these two related disease states. Nach Diskussion der funktionellen und morphologischen Ursachen der Diffusionsstörungen wird die Bedeutung der atemphysiologischen Untersuchungen für diese beiden verwandten Krankheitsbilder aufgezeigt.
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